Dj ns production 20198/27/2023 ![]() As an antioxidant protein, DJ-1 not only eliminates peroxide under oxidative stress by auto-oxidation but also regulates the transcription of NRF2 and its target genes (Biosa et al., 2017 Clements et al., 2006). ![]() Later, DJ-1 was reported to sense and protect against oxidative stress in neuronal cells (Biosa et al., 2017 Taira et al., 2004 Zhang et al., 2018). It was first identified as an oncogene and later a causative gene for autosomal recessive early-onset Parkinson’s disease (Bonifati et al., 2003 Nagakubo et al., 1997). DJ-1 is considered to be a key regulator of cellular redox homeostasis.
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